Klein, Silvan and Aung, Thiha and Haas, Robert Michael and Medved, Fabian and Schiller, Stefan M. and Felthaus, Oliver and Dolderer, Juergen H. (2018) Tissue engineering of adipose tissue with biodegradable biomaterials for soft tissue reconstruction. HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE, 50 (2). pp. 83-92. ISSN 0722-1819, 1439-3980
Full text not available from this repository. (Request a copy)Abstract
Soft tissue defects resulting from injuries, tumor resection, congenital anomalies or chronic wounds pose a great challenge to reconstructive surgery. The current gold standard in therapy of such defects is the tissue transplantation in terms of free or local flaps. Unfortunately, donor site morbidity remains a considerable risk of flap surgery. Therefore, tissue engineering of autologous vascularized long term stable adipose tissue constructs could enrich the therapeutic possibilities of soft tissue defects. De novo adipose tissue growing requires fundamental knowledge about this kind of tissue and its synthesis, closely linked to angiogenesis. Bioresorbable biomaterials (scaffolds) are of crucial importance for adipose tissue engineering. Simulation or replacement of extracellular matrix for tissue growth by scaffold application requires a profound understanding of cell-matrix interactions. A proper biomaterial should be capable of supporting cell adherence, proliferation and differentiation. Important features are biocompatibility and resorption without toxic metabolites. In this review, various scaffold materials are discussed and novel achievements are presented. Persisting problems of de novo adipose tissue formation are high resorption rates and small tissue volumes of adipose constructs. Adipose tissue formation in a tissue engineering chamber is an additional possibility for in vivo tissue engineering. Recent studies proof that long term stable de novo adipose tissue formation of clinically relevant tissue volumes is possible. This method, in our opinion, has the potential to improve therapeutic strategies of soft tissue defects significantly.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FIBROBLAST-GROWTH-FACTOR; PEDICLED FAT FLAP; LONG-TERM; IN-VITRO; STEM-CELLS; HUMAN PREADIPOCYTES; LOCAL-DELIVERY; STROMAL CELLS; SCAFFOLDS; ANGIOGENESIS; tissue engineering; biomaterials; adipose tissue-soft tissue defect reconstructive surgery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Jun 2020 13:37 |
| Last Modified: | 26 Jun 2020 13:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14763 |
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