Schneider, Magdalena and Angele, Peter and Jarvinen, Tero A. H. and Docheva, Denitsa (2018) Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing. ADVANCED DRUG DELIVERY REVIEWS, 129. pp. 352-375. ISSN 0169-409X, 1872-8294
Full text not available from this repository. (Request a copy)Abstract
Due to the increasing age of our society and a rise in engagement of young people in extreme and/or competitive sports, both tendinopathies and tendon ruptures present a clinical and financial challenge. Tendon has limited natural healing capacity and often responds poorly to treatments, hence it requires prolonged rehabilitation in most cases. Till today, none of the therapeutic options has provided successful long-term solutions, meaning that repaired tendons do not recover their complete strength and functionality. Our understanding of tendon biology and healing increases only slowly and the development of new treatment options is insufficient. In this review, following discussion on tendon structure, healing and the clinical relevance of tendon injury, we aim to elucidate the role of stem cells in tendon healing and discuss new possibilities to enhance stem cell treatment of injured tendon. To date, studies mainly apply stem cells, often in combination with scaffolds or growth factors, to surgically created tendon defects. Deeper understanding of how stem cells and vasculature in the healing tendon react to growth factors, common drugs used to treat injured tendons and promising cellular boosters could help to develop new and more efficient ways to manage tendon injuries. (C) 2017 The Author(s). Published by Elsevier B.V.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-I; OXIDE SYNTHASE ISOFORMS; INDUCED TENOGENIC DIFFERENTIATION; ULTRASOUND-GUIDED SCLEROSIS; MESENCHYMAL STROMAL CELLS; ROTATOR CUFF TEARS; TERM-FOLLOW-UP; FLEXOR TENDON; BONE-MARROW; PATELLAR TENDON; Tendon Tendon repair growth factors; Mesenchymal stem cells; Bone marrow derived mesenchymal stem cells; Adipose tissue derived mesenchymal stem cells; Perivascular cells; Tendon-derived cells; Tendon stem/progenitor cells; Tendon vasculature; Cellular boosters |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Jun 2020 11:09 |
| Last Modified: | 26 Jun 2020 11:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14804 |
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