Alter, Peter and Watz, Henrik and Kahnert, Kathrin and Pfeifer, Michael and Randerath, Winfried J. and Andreas, Stefan and Waschki, Benjamin and Kleibrink, Bjorn E. and Welte, Tobias and Bals, Robert and Schulz, Holger and Biertz, Frank and Young, David and Vogelmeier, Claus F. and Jorres, Rudolf A. (2018) Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling. RESPIRATORY MEDICINE, 137. pp. 14-22. ISSN 0954-6111, 1532-3064
Full text not available from this repository. (Request a copy)Abstract
Aims: Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases are thought to be linked through various factors. We aimed to assess the relationship between airway obstruction, lung hyperinflation and diastolic filling in COPD. Methods: The study population was a subset of the COPD cohort COSYCONET. Echocardiographic parameters included the left atrial diameter (LA), early (E) and late (A) transmitral flow, mitral annulus velocity (e'), E wave deceleration time (E[dt]), and isovolumic relaxation time (IVRT). We quantified the effect of various predictors including forced expiratory volume in 1 s (FEV1) and intrathoracic gas volume (ITGV) on the echocardiographic parameters by multiple linear regression and integrated the relationships into a path analysis model. Results: A total of 615 COPD patients were included (mean FEV1 52.6% predicted). In addition to influences of age, BMI and blood pressure, ITGV was positively related to e'-septal and negatively to LA, FEV1 positively to E(dt) (p < 0.05 each). The effect of predictors was most pronounced for LA, e'-septal and E(dt), and less for E/A, IVRT and E/e'. Path analysis was used to take into account the additional relationships between the echocardiographic parameters themselves, demonstrating that their associations with the predictors were maintained and robust. Conclusions: Airway obstruction and lung hyperinflation were significantly associated with cardiac diastolic filling in patients with COPD, suggesting a decreased preload rather than an inherently impaired myocardial relaxation itself. This suggests that a reduction in obstruction and hyperinflation could help to improve cardiac filling.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DECOMPENSATED HEART-FAILURE; LATE GADOLINIUM ENHANCEMENT; PULMONARY-DISEASE; WALL STRESS; MYOCARDIAL-INFARCTION; INFLAMMATORY MARKERS; IMPACT; DYSFUNCTION; COMORBIDITIES; PREVALENCE; COPD; Airway obstruction; Hyperinflation; Diastolic filling; Dyspnea; Heart failure; HFpEF |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2020 08:34 |
| Last Modified: | 20 Mar 2020 08:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14844 |
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