Koch, M. and Utpatel, K. and Schulz, C. (2018) Hyponatremia in a 58-year-old female patient with EGFR-positive lung adenocarcinoma. INTERNIST, 59 (4). pp. 384-387. ISSN 0020-9554, 1432-1289
Full text not available from this repository. (Request a copy)Abstract
The case of a 58-year old female patient with epidermal growth factor-positive pulmonary adenocarcinoma treated with the tyrosine kinase inhibitor afatinib is reported. After several months of first-line therapy the patient developed severe hyponatremia and tumor reassessment revealed a progressive course of the lung cancer. Rebiopsy showed transformation of the tumor into small-cell lung cancer. Therapy with afatinib was stopped immediately and platin-based chemotherapy was started. This case shows that tumor transformation under tyrosine kinase inhibitor therapy from non-small-cell into small-cell lung cancer can occur in rare cases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSFORMATION; CANCER; Non-small-cell lung cancer; Small-cell lung cancer; Tyrosine kinase inhibitor; Afatinib; Biopsy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Mar 2020 10:23 |
| Last Modified: | 11 Mar 2020 10:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14849 |
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