Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention

Mahabir, Somdat and Willett, Walter C. and Friedenreich, Christine M. and Lai, Gabriel Y. and Boushey, Carol J. and Matthews, Charles E. and Sinha, Rashmi and Colditz, Graham A. and Rothwell, Joseph A. and Reedy, Jill and Patel, Alpa V. and Leitzmann, Michael F. and Fraser, Gary E. and Ross, Sharon and Hursting, Stephen D. and Abnet, Christian C. and Kushi, Lawrence H. and Taylor, Philip R. and Prentice, Ross L. (2018) Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 27 (3). pp. 233-244. ISSN 1055-9965, 1538-7755

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Abstract

Very large international and ethnic differences in cancer rates exist, are minimally explained by genetic factors, and show the huge potential for cancer prevention. A substantial portion of the differences in cancer rates can be explained by modifiable factors, and many important relationships have been documented between diet, physical activity, and obesity, and incidence of important cancers. Other related factors, such as the microbiome and the metabolome, are emerging as important intermediary components in cancer prevention. It is possible with the incorporation of newer technologies and studies including long follow up and evaluation of effects across the life cycle, additional convincing results will be produced. However, several challenges exist for cancer researchers; for example, measurement of diet and physical activity, and lack of standardization of samples for microbiome collection, and validation of metabolomic studies. The United States National Cancer Institute convened the Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention Workshop on June 28-29, 2016, in Rockville, Maryland, during which the experts addressed the state of the science and areas of emphasis. This current paper reflects the state of the science and priorities for future research. (C) 2017 AACR.

Item Type: Article
Uncontrolled Keywords: RANDOMIZED CONTROLLED-TRIAL; FOOD FREQUENCY QUESTIONNAIRE; MEASUREMENT ERROR-CORRECTION; ESTIMATE CALCIUM INTAKE; FAT DIETARY PATTERN; BREAST-CANCER; HUMAN MICROBIOME; PROSTATE-CANCER; GUT MICROBIOME; FECAL SAMPLES;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Institut für Epidemiologie und Präventivmedizin
Depositing User: Petra Gürster
Date Deposited: 26 Jun 2020 10:00
Last Modified: 26 Jun 2020 10:00
URI: https://pred.uni-regensburg.de/id/eprint/14918

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