Koehler, Julia and Brandl, Ferdinand P. and Goepferich, Achim M. (2018) Hydrogel wound dressings for bioactive treatment of acute and chronic wounds. EUROPEAN POLYMER JOURNAL, 100. pp. 1-11. ISSN 0014-3057, 1873-1945
Full text not available from this repository. (Request a copy)Abstract
Hydrogel-based wound dressings are one of the most promising materials in wound care, fulfilling important dressing requirements, including: (a) keeping the wound moist whilst absorbing extensive exudate, (b) adhesion free coverage of sensitive underlying tissue, (c) pain reduction through cooling and (d) a potential for active intervention in the wound healing process. Although numerous hydrogel-based dressings are already on the market, new wound care treatment options are urgently required to address the growing number of severe, acute and chronic wounds experienced by today's aging society. High cost, safety concerns surrounding the use of drugs and allogeneic/xenogeneic materials, and issues specific to hydrogels, such as lack of mechanical stability, are impeding clinical implementation of many novel approaches. To meet clinical needs, the development of new hydrogel wound dressings that overcome these drawbacks would be desirable. This review provides a broad overview of recent progress - commercial and scientific - in the field of bioactive hydrogel wound dressings. A variety of approaches to bioactive wound healing, such as bioactive dressing materials, use of antimicrobial agents, inclusion of biological signaling molecules like growth factors, and incorporation of seeded stem cells, are considered and critically evaluated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DOUBLE-NETWORK HYDROGELS; SITU-FORMING HYDROGEL; GROWTH-FACTOR; CHITOSAN HYDROGEL; HYALURONIC-ACID; STEM-CELLS; ANTIMICROBIAL ACTIVITY; HUMAN KERATINOCYTES; GELATIN HYDROGEL; ESSENTIAL OILS; Alginate; Antimicrobial agent; Interpenetrating polymer network hydrogel; pH-modifying hydrogel; Stem cell; Wound dressing |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Jun 2020 09:57 |
| Last Modified: | 26 Jun 2020 09:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14923 |
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