Markus, M. R. P. and Ittermann, T. and Baumeister, S. E. and Huth, C. and Thorand, B. and Herder, C. and Roden, M. and Siewert-Markus, U. and Rathmann, W. and Koenig, W. and Doerr, M. and Voelzke, H. and Schipf, S. and Meisinger, C. (2018) Prediabetes is associated with microalbuminuria, reduced kidney function and chronic kidney disease in the general population The KORA (Cooperative Health Research in the Augsburg Region) F4-Study. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 28 (3). pp. 234-242. ISSN 0939-4753, 1590-3729
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Background and Aims: We investigated the associations of serum fasting (FG) and 2-h postload (2HG) glucose from an oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), fasting insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) with urinary albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR). Methods and Results: We performed cross-sectional analyses of 2713 subjects (1429 women; 52.7%) without known type 2 diabetes, aged 31-82 years, from the KORA (Cooperative Health Research in the Augsburg Region) F4-Study. FG, 2HG, HbA1c, fasting insulin, HOMA-IR and glucose tolerance categories were analyzed for association with ACR and eGFR in multivariable adjusted linear and median regression models, and with isolated microalbuminuria (i-MA), isolated reduced kidney function (i-RKF) and chronic kidney disease (CKD, defined as MA and/or RKF) in multivariable adjusted logistic regression models. Among the 2713 study participants, 28% revealed prediabetes (isolated impaired fasting glucose [i-IFG], isolated glucose tolerance [i-IGT] or both by American Diabetes Association definition), 4.2% had unknown type 2 diabetes, 6.5% had i-MA, 3.1% i-RKF and 10.9% CKD. In multivariable adjusted analysis, all continuous variables (FG, 2HG, HbA1c, fasting insulin and HOMA-IR) were associated with i-MA, i-RKF and CKD. The odds ratios (ORs) for i-MA and CKD were 1.54 (95% confidence interval: 1.02-2.33) and 1.58 (1.10-2.25) for individuals with i-IFG. Moreover, the OR for i-RKF was 2.57 (1.31-5.06) for individuals with IFG + IGT. Conclusion: Our findings suggest that prediabetes might have harmful effects on the kidney. (C) 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLUCOSE; GLYCEMIA; BURDEN; MODEL; CKD; Albuminuria; Chronic kidney disease; Diabetes; Insulin resistance; Microalbuminuria |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2020 12:21 |
| Last Modified: | 12 Mar 2020 12:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14932 |
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