Wobser, Hella and Paur, Tanja and Schnoy, Elisabeth and Hartl, Janine and Kirchner, Gabriele I. (2018) Suitability of the simplified autoimmune hepatitis score for the diagnosis of autoimmune hepatitis in a German cohort. UNITED EUROPEAN GASTROENTEROLOGY JOURNAL, 6 (2). pp. 247-254. ISSN 2050-6406, 2050-6414
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Background: Several years ago the International Autoimmune Hepatitis Group simplified the previous revised original scoring system for diagnosis of autoimmune hepatitis (AIH) into a scoring system based on only four instead of 13 parameters. Objective: We aimed to evaluate the suitability of the simplified AIH score for diagnosis of AIH in a German cohort with chronic liver diseases. Methods: In this retrospective single-center study, we compared the accuracy of both AIH scores in 70 patients with AIH and 211 patients with chronic liver diseases (PBC (n=52), PSC (n=27), NASH (n=67), DILI (n=15), CHB/C (n=50)). Sensitivity, specificity and predictability of each scoring system were calculated. Results: Using the simplified AIH score, the sensitivity and specificity of detecting a probable AIH (scores >= 6) were 96% and 97% with a positive and negative predictive value of 92% and 99%, respectively. For diagnosis of definite AIH (scores >= 7), the sensitivity and specificity were 43% and 100% with a positive and negative predictive value of 97% and 84%, respectively. The concordance with the revised original criteria was 63%. The specificity for excluding AIH was excellent in both scoring system. Conclusion: The simplified diagnostic criteria allow a reliable diagnosis of AIH in a German cohort.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRIMARY BILIARY-CIRRHOSIS; INDUCED LIVER-INJURY; CLINICAL-FEATURES; MANAGEMENT; CRITERIA; DISEASE; PERFORMANCE; PROGNOSIS; SYSTEM; VIRUS; Autoimmune hepatitis (AIH); diagnostic scores; simplified criteria; revised original criteria; routine clinical practice |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2020 13:26 |
| Last Modified: | 12 Mar 2020 13:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14953 |
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