Knorr, R. and Schoellkopf, J. and Haen, E. (2018) Neuroleptic malignant syndrome. NERVENARZT, 89 (3). pp. 300-310. ISSN 0028-2804, 1433-0407
Full text not available from this repository. (Request a copy)Abstract
Neuroleptic malignant syndrome (NMS) is a rare but severe undesired complication of psychopharmacological treatment. The mortality has shown a significant decrease since its first description. Knowledge of NMS is important for every clinician because of the need for rapid diagnosis and treatment. This article presents a review and critical appraisal of the current study situation for NMS. Recommendations for diagnostics, differential diagnostics and treatment are presented particularly from a clinical perspective. A literature review with the keywords "neuroleptic malignant syndrome", "Malignes neuroleptisches Syndrom" and various psychotropic drugs was performed in PubMed. The database of the Working Group for Pharmaceutical Treatment of Psychiatric Diseases (Arbeitsgemeinschaft fur Arzneimitteltherapie bei psychiatrischen Erkrankungen, AGATE) was analyzed with respect to registered cases of the undesired side effect NMS. In contrast to the first description, which also led to the name, there are now case reports of clinical conditions similar to NMS, which were obviously triggered by several groups of psychotropic drugs not just antipsychotic agents (German: Neuroleptika). Treatment recommendations exist whereby the effectiveness cannot always be scientifically substantiated; however, it is still undisputed that a rapid initiation of treatment is of great importance. The psychiatrist must be familiar with the symptoms of NMS, its differential diagnosis and the therapeutic options for a rapid and effective treatment. Further studies are urgently needed for scientific substantiation of the pathophysiology of NMS and to develop evidence-based guidelines for treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ELECTROCONVULSIVE-THERAPY; INTERNATIONAL CONSENSUS; DIAGNOSTIC-CRITERIA; CLOZAPINE; DRUG; PATHOPHYSIOLOGY; ANTIPSYCHOTICS; RECHALLENGE; MODULATION; INJECTION; Risk factors; Differential diagnoses; Symptoms; Psychopharmacotherapy; Dopamine antagonists |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Jun 2020 11:01 |
| Last Modified: | 25 Jun 2020 11:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14983 |
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