Lorentzen, Anna and Becker, Paul F. and Kosla, Jan and Saini, Massimo and Weidele, Kathrin and Ronchi, Paolo and Klein, Corinna and Wolf, Monika J. and Geist, Felix and Seubert, Bastian and Ringelhan, Marc and Mihic-Probst, Daniela and Esser, Knud and Roblek, Marko and Kuehne, Felix and Bianco, Gaia and O'Connor, Tracy and Mueller, Quentin and Schuck, Kathleen and Lange, Sebastian and Hartmann, Daniel and Spaich, Saskia and Gross, Olaf and Utikal, Jochen and Haferkamp, Sebastian and Sprick, Martin R. and Damle-Vartak, Amruta and Hapfelmeier, Alexander and Hueser, Norbert and Protzer, Ulrike and Trumpp, Andreas and Saur, Dieter and Vartak, Nachiket and Klein, Christoph A. and Polzer, Bernhard and Borsig, Lubor and Heikenwalder, Mathias (2018) Single cell polarity in liquid phase facilitates tumour metastasis. NATURE COMMUNICATIONS, 9: 887. ISSN 2041-1723,
Full text not available from this repository. (Request a copy)Abstract
Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from different tumour entities that is observed in circulating tumour cells in patients. Functionally, we propose that the sc pole is directly involved in early attachment, thereby affecting adhesion, transmigration and metastasis. In vivo, the metastatic capacity of cell lines correlates with the extent of sc polarisation. By manipulating sc polarity regulators and by generic depolarisation, we show that sc polarity prior to migration affects transmigration and metastasis in vitro and in vivo.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MELANOMA; CANCER; RESISTANCE; ERM; CONTRACTILITY; MECHANISMS; EXPRESSION; SIMILARITY; MOVEMENT; PROTEINS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für experimentelle Medizin und Therapieverfahren |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Mar 2020 11:04 |
| Last Modified: | 19 Mar 2020 11:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15014 |
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