Schatz, Valentin and Neubert, Patrick and Rieger, Franz and Jantsch, Jonathan (2018) Hypoxia, Hypoxia-inducible Factor-1 alpha, and Innate Antileishmanial Immune Responses. FRONTIERS IN IMMUNOLOGY, 9: 216. ISSN 1664-3224
Full text not available from this repository. (Request a copy)Abstract
Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation in leishmanial lesions. Moreover, we review the role of hypoxia and HIF-1 on innate antileishmanial immune responses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; MOUSE PERITONEAL-MACROPHAGES; LEISHMANIA-MAJOR INFECTION; FACTOR 1-ALPHA; CUTANEOUS LEISHMANIASIS; DEPENDENT REGULATION; REACTIVE NITROGEN; HOST MACROPHAGES; INTERFERON-GAMMA; hypoxia-inducible factor 1; leishmaniasis; macrophages; oxygen; Nos2; hypoxia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Jun 2020 10:15 |
| Last Modified: | 25 Jun 2020 10:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15024 |
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