Mayr, Judith and Saldias, Cesar and Diaz Diaz, David (2018) Release of small bioactive molecules from physical gels. CHEMICAL SOCIETY REVIEWS, 47 (4). pp. 1484-1515. ISSN 0306-0012, 1460-4744
Full text not available from this repository. (Request a copy)Abstract
Pharmaceutical drugs with low water solubility have always received great attention within the scientific community. The reduced bioavailability and the need of frequent administrations have motivated the investigation of new drug delivery systems. Within this context, drug carriers that release their payload in a sustained way and hence reduce the administration rate are highly demanded. One interesting strategy to meet these requirements is the entrapment of the drugs into gels. So far, the most investigated materials for such drug-loaded gels are derived from polymers and based on covalent linkages. However, over the last decade the use of physical (or supramolecular) gels derived from low molecular weight compounds has experienced strong growth in this field, mainly due to important properties such as injectability, stimuli responsiveness and ease of synthesis. This review summarizes the use of supramolecular gels for the encapsulation and controlled release of small therapeutic molecules.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONSTEROIDAL ANTIINFLAMMATORY DRUG; SELF-ASSEMBLED HYDROGELS; ORAL CONTROLLED-RELEASE; PHASE-SEPARATION GEL; SUPRAMOLECULAR HYDROGELS; DELIVERY SYSTEM; AMINO-ACID; L-ALANINE; IN-VITRO; ANTITUMOR-ACTIVITY; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Jun 2020 10:18 |
| Last Modified: | 25 Jun 2020 10:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15025 |
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