Graessel, Susanne and Muschter, Dominique (2018) Do Neuroendocrine Peptides and Their Receptors Qualify as Novel Therapeutic Targets in Osteoarthritis? INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19 (2): 367. ISSN 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Joint tissues like synovium, articular cartilage, meniscus and subchondral bone, are targets for neuropeptides. Resident cells of these tissues express receptors for various neuroendocrine-derived peptides including proopiomelanocortin (POMC)-derived peptides, i.e., -melanocyte-stimulating hormone (-MSH), adrenocorticotropin (ACTH) and -endorphin (-ED), and sympathetic neuropeptides like vasoactive intestinal peptide (VIP) and neuropeptide y (NPY). Melanocortins attained particular attention due to their immunomodulatory and anti-inflammatory effects in several tissues and organs. In particular, -MSH, ACTH and specific melanocortin-receptor (MCR) agonists appear to have promising anti-inflammatory actions demonstrated in animal models of experimentally induced arthritis and osteoarthritis (OA). Sympathetic neuropeptides have obtained increasing attention as they have crucial trophic effects that are critical for joint tissue and bone homeostasis. VIP and NPY are implicated in direct and indirect activation of several anabolic signaling pathways in bone and synovial cells. Additionally, pituitary adenylate cyclase-activating polypeptide (PACAP) proved to be chondroprotective and, thus, might be a novel target in OA. Taken together, it appears more and more likely that the anabolic effects of these neuroendocrine peptides or their respective receptor agonists/antagonists may be exploited for the treatment of patients with inflammatory and degenerative joint diseases in the future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VASOACTIVE-INTESTINAL-PEPTIDE; NEUROPEPTIDE-Y; RHEUMATOID-ARTHRITIS; ALPHA-MSH; PANCREATIC-POLYPEPTIDE; ADENYLATE-CYCLASE; SYNOVIAL-FLUID; DISEASE; RAT; VIP; proopiomelanocortin; alpha-MSH; VIP; NPY; osteoarthritis; neuroendocrine; PACAP |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Jun 2020 09:21 |
| Last Modified: | 25 Jun 2020 09:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15095 |
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