Corbacioglu, S. and Carreras, E. and Ansari, M. and Balduzzi, A. and Cesaro, S. and Dalle, J-H and Dignan, F. and Gibson, B. and Guengoer, T. and Gruhn, B. and Lankester, A. and Locatelli, F. and Pagliuca, A. and Peters, C. and Richardson, P. G. and Schulz, A. S. and Sedlacek, P. and Stein, J. and Sykora, K-W and Toporski, J. and Trigoso, E. and Vetteranta, K. and Wachowiak, J. and Wallhult, E. and Wynn, R. and Yaniv, I. and Yesilipek, A. and Mohty, M. and Bader, P. (2018) Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation. BONE MARROW TRANSPLANTATION, 53 (2). pp. 138-145. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that belongs to a group of diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within weeks; however, severe SOS/VOD results in multi-organ dysfunction/failure with a mortality rate > 80%. A timely diagnosis of SOS/VOD is of critical importance, given the availability of therapeutic options with favorable tolerability. Current diagnostic criteria are used for adults and children. However, over the last decade it has become clear that SOS/VOD is significantly different between the age groups in terms of incidence, genetic predisposition, clinical presentation, prevention, treatment and outcome. Improved understanding of SOS/VOD and the availability of effective treatment questions the use of the Baltimore and Seattle criteria for diagnosing SOS/VOD in children. The aim of this position paper is to propose new diagnostic and severity criteria for SOS/VOD in children on behalf of the European Society for Blood and Marrow Transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; HEPATIC VENOOCCLUSIVE DISEASE; GEMTUZUMAB OZOGAMICIN EXPOSURE; ACUTE LYMPHOBLASTIC-LEUKEMIA; HIGH-RISK NEUROBLASTOMA; HIGH-DOSE CHEMOTHERAPY; INTRAVENOUS BUSULFAN; VENOCCLUSIVE DISEASE; MYELOABLATIVE CHEMOTHERAPY; DOPPLER-ULTRASONOGRAPHY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Mar 2020 08:57 |
| Last Modified: | 19 Mar 2020 08:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15128 |
Actions (login required)
 |
View Item |
