Kasmann, Lukas and Niyazi, Maximilian and Blanck, Oliver and Baues, Christian and Baumann, Rene and Dobiasch, Sophie and Eze, Chukwuka and Fleischmann, Daniel and Gauer, Tobias and Giordano, Frank A. and Goy, Yvonne and Hausmann, Jan and Henkenberens, Christoph and Kaul, David and Klook, Lisa and Krug, David and Maeurer, Matthias and Panje, Cedric M. and Rosenbrock, Johannes and Sautter, Lisa and Schmitt, Daniela and Suess, Christoph and Thieme, Alexander H. and Trommer-Nestler, Maike and Ziegler, Sonia and Ebert, Nadja and Medenwald, Daniel and Ostheimer, Christian (2018) Predictive and prognostic value of tumor volume and its changes during radical radiotherapy of stage III non-small cell lung cancer: A systematic review. STRAHLENTHERAPIE UND ONKOLOGIE, 194 (2). pp. 79-90. ISSN 0179-7158, 1439-099X
Full text not available from this repository. (Request a copy)Abstract
Lung cancer remains the leading cause of cancer-related mortality worldwide. Stage III non-small cell lung cancer (NSCLC) includes heterogeneous presentation of the disease including lymph node involvement and large tumour volumes with infiltration of the mediastinum, heart or spine. In the treatment of stage III NSCLC an interdisciplinary approach including radiotherapy is considered standard of care with acceptable toxicity and improved clinical outcome concerning local control. Furthermore, gross tumour volume (GTV) changes during definitive radiotherapy would allow for adaptive replanning which offers normal tissue sparing and dose escalation. A literature review was conducted to describe the predictive value of GTV changes during definitive radiotherapy especially focussing on overall survival. The literature search was conducted in a two-step review process using PubMedA (R)/MedlineA (R) with the key words "stage III non-small cell lung cancer" and "radiotherapy" and "tumour volume" and "prognostic factors". After final consideration 17, 14 and 9 studies with a total of 2516, 784 and 639 patients on predictive impact of GTV, GTV changes and its impact on overall survival, respectively, for definitive radiotherapy for stage III NSCLC were included in this review. Initial GTV is an important prognostic factor for overall survival in several studies, but the time of evaluation and the value of histology need to be further investigated. GTV changes during RT differ widely, optimal timing for re-evaluation of GTV and their predictive value for prognosis needs to be clarified. The prognostic value of GTV changes is unclear due to varying study qualities, re-evaluation time and conflicting results. The main findings were that the clinical impact of GTV changes during definitive radiotherapy is still unclear due to heterogeneous study designs with varying quality. Several potential confounding variables were found and need to be considered for future studies to evaluate GTV changes during definitive radiotherapy with respect to treatment outcome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTENSITY-MODULATED RADIOTHERAPY; 3D CONFORMAL RADIOTHERAPY; RADIATION-THERAPY; CONCURRENT CHEMORADIOTHERAPY; F-18-FDG PET/CT; DOSE-ESCALATION; PHASE-III; TNM STAGE; SURVIVAL; CT; Stage III lung cancer; Literature review; Clinical multicenter trial; Tumor volume changes; Definitive radiotherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Jun 2020 08:53 |
| Last Modified: | 25 Jun 2020 08:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15146 |
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