Bundscherer, Anika C. and Malsy, Manuela and Gruber, Michael A. and Graf, Bernhard M. and Sinner, Barbara (2018) Acetaminophen and Metamizole Induce Apoptosis in HT 29 and SW 480 Colon Carcinoma Cell Lines In Vitro. ANTICANCER RESEARCH, 38 (2). pp. 745-751. ISSN 0250-7005, 1791-7530
Full text not available from this repository. (Request a copy)Abstract
Background/Aim: The perioperative phase is supposed to be a period with high vulnerability for cancer dissemination. Acetaminophen and metamizole are common analgesics administered during this phase. We investigated the effect of acetaminophen, metamizole and 4-methylaminoantipyrine (MAA) on proliferation and apoptosis of colon carcinoma cell lines (SW 480 and HT 29). Materials and Methods: Proliferation was detected by cell proliferation ELISA BrdU, and apoptosis by Annexin V staining. Cytochrome c and caspase 3, 8 and 9 expression levels were detected by western blot. Results: Acetaminophen, metamizole or MAA caused slight changes in proliferation. Acetaminophen, metamizole or the combination increased apoptosis in both cell lines. All agents decreased caspase 3 and 8 expression in SW480. Acetaminophen decreased caspase 9 expression in both cell lines. Conclusion: In clinically relevant doses, acetaminophen and/or metamizole induce apoptosis in both colon cancer cell lines. Both mitochondrial and death receptor pathways might be involved in acetaminophen-induced apoptosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BREAST-CANCER CELLS; ANESTHETIC TECHNIQUE; GROWTH; ACID; PROLIFERATION; PARACETAMOL; RECURRENCE; EXPRESSION; INCREASES; DIPYRONE; Cancer; acetaminophen; metamizole; cell proliferation; apoptosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2020 12:51 |
| Last Modified: | 20 Mar 2020 12:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15148 |
Actions (login required)
 |
View Item |
