Schmitt, Volker H. and Mamilos, Andreas and Schmitt, Christine and Neitzer-Planck, Constanze N. E. and Rajab, Taufiek K. and Hollemann, David and Wagner, Willi and Kraemer, Bernhard and Hierlemann, Helmut and Kirkpatrick, C. James and Brochhausen, Christoph (2018) Tissue response to five commercially available peritoneal adhesion barriers-A systematic histological evaluation. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 106 (2). pp. 598-609. ISSN 1552-4973, 1552-4981
Full text not available from this repository. (Request a copy)Abstract
Separating wounded serosa by physical barriers is the only clinically approved adjunct for postoperative adhesion prevention. Since the optimal adhesion barrier has not been found, it is essential to improve our pathogenic understanding of adhesion formation and to compare the effects of different barrier materials on tissue and cells. Wistar rats underwent standardized peritoneal damage and were treated either with Seprafilm, Adept, Intercoat, Spraygel, SupraSeal or remained untreated as a control. 14 days postoperatively, the lesions were explanted and histomorphologically analyzed using the European ISO score to evaluate material implants. Striking differences between the material groups were present regarding the inflammation, fibrosis, and foreign body reaction. According to the ISO score, Intercoat and Spraygel were considered as nonirritating to tissue. Adept, Seprafilm, and SupraSeal were assessed as mild-irritating materials. Interestingly, the most effective material in adhesion prevention revealed moderate inflammation accompanied by minor fibrosis. The degree of inflammation to barrier materials does not predict the efficacy in the prevention of adhesions. Histopathological investigations are crucial to improve our understanding of the cellular mechanisms during adhesion formation and elucidate the tissue response to material approaches used in adhesion prevention. This will lead to improved antiadhesive strategies and the development of functional barrier biomaterials. (c) 2017 Wiley Periodicals, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DOUBLE-BLIND; MULTICENTER; PREVENTION; REDUCTION; SEPRAFILM; MEMBRANE; VASCULARIZATION; MYOMECTOMY; FIBROSIS; EFFICACY; peritoneal adhesion; barrier materials; adhesion prevention; histomorphology; mesothelial cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2020 14:37 |
| Last Modified: | 20 Mar 2020 14:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15167 |
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