Probst, Ute and Sieron, Dominik and Bruenn, Karin and Fuhrmann, Irene and Verloh, Niklas (2018) Efficacy of dynamic enhancement effects on Gd-EOB-DTPA-enhanced MRI for estimation of liver function assessed by C-13-Methacetin breath test. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 70 (4). pp. 595-604. ISSN 1386-0291, 1875-8622
Full text not available from this repository. (Request a copy)Abstract
PURPOSE: Contrast enhanced magnetic resonance imaging (MRI) is able to assess liver function by characteristic changes of signal intensity (SI). The aim was to evaluate dynamic contrast-enhanced SI-indices of the abdominal aorta, portal vein and liver. METHODS: 72 patients underwent Gd-EOB-DTPA-enhanced MRI and a C-13-methacetin-based liver breath test (C-13-MBT) for evaluation of liver function. Region-of-interest measurements in the liver, abdominal aorta and portal vein during native, arterial (AP), late arterial (LAP), portal venous (PVP) and hepatobiliary phase (HBP) were applied to analyze SI-indices in T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat-suppression and relative enhancement (RE) analysis was performed. RESULTS: The liver (p < 0.001), the portal vein (p < 0.001) and abdominal aorta (p= 0.002) showed significant decrease of REs with decreasing liver function. An increasing trend between logarithmic values of C-13-MBT and REs of hepatic parenchyma (HBP; r= 0.662, p < 0.001), portal vein (PVP; r= 0.532, p < 0.001) and abdominal aorta (PVP; r= 0.421, p <0 .001) was observed. CONCLUSIONS: RE measurements of the hepatic parenchyma proofed to be a trustable evaluation method for liver function evaluation. In accordance with liver function, changes of REs in the portal vein and abdominal aorta occur.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATIC PERFUSION; PORTAL-HYPERTENSION; CIRRHOSIS; LIMAX; DIAGNOSIS; Dynamic contrast enhanced MRI; C-13-methacetin liver function breath test; HCC; liver metastases; hepatic parenchyma; portal vein; abdominal aorta; signal intensity; relative enhancement |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2020 06:05 |
| Last Modified: | 20 Mar 2020 06:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15236 |
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