Cieplik, Fabian and Wimmer, Fabian and Muehler, Denise and Thurnheer, Thomas and Belibasakis, Georgios N. and Hiller, Karl-Anton and Maisch, Tim and Buchalla, Wolfgang (2018) Phenalen-1-One-Mediated Antimicrobial Photodynamic Therapy and Chlorhexidine Applied to a Novel Caries Biofilm Model. CARIES RESEARCH, 52 (6). pp. 447-453. ISSN 0008-6568, 1421-976X
Full text not available from this repository. (Request a copy)Abstract
Antimicrobial photodynamic therapy (aPDT) may be useful as a supportive antimicrobial measure for caries-active subjects. In this study, the antimicrobial efficacy of aPDT with a phenalen-1-one photosensitizer was evaluated in a novel in vitro biofilm model comprising Actinomyces naeslundii, Actinomyces odontolyticus, and Streptococcus mutans and was compared to chlorhexidine. The proposed biofilm model allows high-throughput screening for antimicrobial efficacy while exhibiting a differentiated response to different antimicrobial approaches. While chlorhexidine 0.2% showed a reduction of approximate to 4 log(10) for all species, aPDT led to a more pronounced reduction of S. mutans (2.8 log(10)) than of Actinomyces spp. (1.2 or 1.3 log(10)). A similar effect was also observed in monospecies biofilms. Therefore, aPDT may be more effective against S. mutans than against Actinomyces spp. when in biofilms, and this antimicrobial approach merits further investigations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACTINOMYCES-NAESLUNDII; STREPTOCOCCUS-MUTANS; SINGLET OXYGEN; RESISTANCE; INACTIVATION; EFFICACY; VALIDATION; DENTISTRY; BACTERIA; IMPACT; Caries; Chlorhexidine; Phenalen-1-one; Photodynamic therapy; Polymicrobial biofilm; Streptococcus mutans |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2020 07:13 |
| Last Modified: | 20 Mar 2020 07:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15254 |
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