Gierth, Michael and Zeman, Florian and Denzinger, Stefan and Vetterlein, Malte W. and Fisch, Margit and Bastian, Patrick J. and Syring, Isabella and Ellinger, Joerg and Mueller, Stephan C. and Herrmann, Edwin and Gilfrich, Christian and May, Matthias and Pycha, Armin and Wagenlehner, Florian M. and Vallo, Stefan and Bartsch, Georg and Haferkamp, Axel and Grimm, Marc-Oliver and Roigas, Jan and Protzel, Chris and Hakenberg, Oliver W. and Fritsche, Hans-Martin and Burger, Maximilian and Aziz, Atiqullah and Mayr, Roman (2018) Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study. UROLOGIA INTERNATIONALIS, 101 (1). pp. 16-24. ISSN 0042-1138, 1423-0399
Full text not available from this repository. (Request a copy)Abstract
Background/Aims/Objectives: To evaluate the influence of body mass index (BMI) on complications and oncological outcomes in patients undergoing radical cystectomy (RC). Methods: Clinical and histopathological parameters of pa-tients have been prospectively collected within the "PRO-spective MulticEnTer RadIcal Cystectomy Series 2011". BMI was categorized as normal weight (< 25 kg/m(2)), overweight (>= 25-29.9 kg/m(2)) and obesity (>= 30 kg/m(2)). The association between BMI and clinical and histopathological endpoints was examined. Ordinal logistic regression models were applied to assess the influence of BMI on complication rate and survival. Results: Data of 671 patients were eligible for final analysis. Of these patients, 26% (n = 175) showed obesity. No significant association of obesity on tumour stage, grade, lymph node metastasis, blood loss, type of urinary diversion and 90-day mortality rate was found. According to the American Society of Anesthesiologists score, local lymph node (NT) stage and operative case load patients with higher BMI had significantly higher probabilities of severe complications 30 days after RC (p = 0.037). The overall survival rate of obese patients was superior to normal weight patients (p = 0.019). Conclusions: There is no evidence of correlation between obesity and worse oncological outcomes after RC. While obesity should not be a parameter to exclude patients from cystectomy, surgical settings need to be aware of higher short-term complication risks and obese patients should be counselled - accordingly. (C) 2018 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WORSE ONCOLOGICAL OUTCOMES; BLADDER-CANCER; BLOOD-LOSS; OBESITY; IMPACT; MORTALITY; RISK; CARCINOMA; COHORT; Urothelial carcinoma; Bladder cancer; Obesity; Radical cystectomy; Prognosis; Survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2020 14:23 |
| Last Modified: | 23 Mar 2020 14:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15293 |
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