Heimer, Sina and Knoll, Gertrud and Steixner, Charlotte and Calance, Diana Nicoleta and Dieu Thuy Trinh, and Ehrenschwender, Martin (2018) Hypertonicity-imposed BCL-XL addiction primes colorectal cancer cells for death. CANCER LETTERS, 435. pp. 23-31. ISSN 0304-3835, 1872-7980
Full text not available from this repository. (Request a copy)Abstract
Induction of mitochondria-controlled (intrinsic) apoptosis is a mainstay of current anti-neoplastic chemotherapies. Activation of this death pathway is counteracted by BCL-2-like proteins, which functionally set the threshold for apoptosis and determine whether malignant cells are sensitive or resistant to anti-cancer treatments. Hence, unlocking the intrinsic apoptotic cascade and promoting the cell's commitment to undergo apoptosis concordantly promotes efficacy of anti-cancer treatments. Here, we show that hyperosmotic stress enforces addiction of colorectal cancer cells to BCL-XL, thereby exhausting the protective capacity of BCL-2-like proteins and priming mitochondria for death. Our work identifies osmotic pressure as a cell extrinsic factor that modulates responsiveness of colorectal cancer cells to therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPEROSMOTIC STRESS; PROTEINS; FAMILY; BAX; MITOCHONDRIA; INHIBITOR; APOPTOSIS; ACTIVATION; PATHWAY; DESIGN; Hyperosmotic stress; BH3 mimetics; BCL-XL; BCL-2; Apoptosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2020 09:23 |
| Last Modified: | 20 Mar 2020 09:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15341 |
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