Janjic, Mila and Docheva, Denitsa and Janjic, Olivera Trickovic and Wichelhaus, Andrea and Baumert, Uwe (2018) In Vitro Weight-Loaded Cell Models for Understanding Mechanodependent Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review. STEM CELLS INTERNATIONAL (specia): 3208285. ISSN 1687-966X, 1687-9678
Full text not available from this repository. (Request a copy)Abstract
Cells from the mesenchymal lineage in the dental area, including but not limited to PDL fibroblasts, osteoblasts, and dental stem cells, are exposed to mechanical stress in physiological (e.g., chewing) and nonphysiological/therapeutic (e.g., orthodontic tooth movement) situations. Close and complex interaction of these different cell types results in the physiological and nonphysiological adaptation of these tissues to mechanical stress. Currently, different in vitro loading models are used to investigate the effect of different types of mechanical loading on the stress adaptation of these cell types. We performed a systematic review according to the PRISMA guidelines to identify all studies in the field of dentistry with focus on mechanobiology using in vitro loading models applying uniaxial static compressive force. Only studies reporting on cells from the mesenchymal lineage were considered for inclusion. The results are summarized regarding gene expression in relation to force duration and magnitude, and the most significant signaling pathways they take part in are identified using protein-protein interaction networks.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERIODONTAL-LIGAMENT CELLS; MECHANICAL-STRESS; GENE-EXPRESSION; COMPRESSIVE STRESS; RECEPTOR ACTIVATOR; PGE(2) PRODUCTION; OPG EXPRESSION; ALVEOLAR BONE; UP-REGULATION; TISSUE MODEL; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Jun 2020 05:35 |
| Last Modified: | 25 Jun 2020 05:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15356 |
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