Engel, Christoph and Neyer, Simon and Cramer, Patrick (2018) Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II. In: UNSPECIFIED Annual Review of Biophysics,, 47 . ANNUAL REVIEWS, PALO ALTO, pp. 425-446. ISBN 978-0-8243-1847-5
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RNA polymerases I and II (Pol I and Pol II) are the eukaryotic enzymes that catalyze DNA-dependent synthesis of ribosomal RNA and messenger RNA, respectively. Recent work shows that the transcribing forms of both enzymes are similar and the fundamental mechanisms of RNA chain elongation are conserved. However, the mechanisms of transcription initiation and its regulation differ between Pol I and Pol II. Recent structural studies of Pol I complexes with transcription initiation factors provided insights into how the polymerase recognizes its specific promoter DNA, how it may open DNA, and how initiation may be regulated. Comparison with the well-studied Pol II initiation system reveals a distinct architecture of the initiation complex and visualizes promoter-and gene-class-specific aspects of transcription initiation. On the basis of new structural studies, we derive a model of the Pol I transcription cycle and provide a molecular movie of Pol I transcription that can be used for teaching.
| Item Type: | Book Section |
|---|---|
| Uncontrolled Keywords: | TATA-BINDING PROTEIN; UPSTREAM ACTIVATION FACTOR; 3.3 ANGSTROM RESOLUTION; RIBOSOMAL DNA GENES; PARTICLE CRYO-EM; STRUCTURAL BASIS; SACCHAROMYCES-CEREVISIAE; CRYSTAL-STRUCTURE; FACTOR UAF; PREINITIATION COMPLEX; transcription initiation; RNA polymerase; structural biology |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Apr 2020 08:12 |
| Last Modified: | 28 Apr 2020 08:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15380 |
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