Paul, Ulrike and Richter, Julia and Stuhlmann-Laiesz, Christiane and Kreuz, Markus and Nagel, Inga and Horn, Heike and Staiger, Annette M. and Aukema, Sietse M. and Hummel, Michael and Ott, German and Spang, Rainer and Rosenwald, Andreas and Feller, Alfred C. and Cogliatti, Sergio and Stein, Harald and Hansmann, Martin-Leo and Moller, Peter and Szczepanowski, Monika and Burkhardt, Birgit and Pfreundschuh, Michael and Schmitz, Norbert and Loeffler, Markus and Truemper, Lorenz and Siebert, Reiner and Klapper, Wolfram (2018) Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC. LEUKEMIA & LYMPHOMA, 59 (5). pp. 1213-1221. ISSN 1042-8194, 1029-2403
Full text not available from this repository. (Request a copy)Abstract
The incidence of diffuse large B-cell lymphoma (DLBCL) increases with age being patient age at diagnosis an adverse prognostic factor. However, elderly patients are often underrepresented in common studies. To investigate the effect between age and biological characteristics in DLBCL, we analyzed data of 1534 patients encompassing all adult age groups, enriched for the age 75 years. Follicular lymphoma (FL) grade 3B with histopathological characteristics of DLBCLs were included. Gender, centroblastic cytology, FL grade 3B morphology, CD10 expression, and ABC/non-GCB-subtype were significantly associated with age after correction for multiple testing and after adjusting for cohorts. Analysis of a subgroup points towards an association of MYC expression with age. Our data indicate that biological features of DLBCL and FL grade 3B are associated with increasing age among adult patients. The prevalence of the ABC/non-GCB-subtype in elderly patients suggests that therapies targeting this molecular subtype should be specifically explored in this subgroup.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 3-WEEKLY CHOP CHEMOTHERAPY; NON-HODGKINS-LYMPHOMA; ELDERLY-PATIENTS; AGGRESSIVE LYMPHOMAS; FOLLICULAR LYMPHOMA; TRIAL; RITUXIMAB; DSHNHL; CLASSIFICATION; TRANSFORMATION; Adult patients; diffuse large B-cell lymphoma; molecular features |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2020 11:55 |
| Last Modified: | 20 Mar 2020 11:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15411 |
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