Burger, Maximilian and Schwaibold, Hartwig and Goebell, Peter and Grimm, Marc-Oliver (2018) Non-invasive bladder cancer. ONKOLOGE, 24 (1). pp. 23-31. ISSN 0947-8965, 1433-0415
Full text not available from this repository. (Request a copy)Abstract
Background. Non-muscle-invasive bladder cancer is a common cancer entity demanding complex diagnostics and treatment. Aim. This review presents the current state of the art of the diagnostics and treatment with an emphasis on risk-adapted patient management. Material and methods. This review is based on a literature search in PubMed for sources on the etiology, diagnostics, treatment and risk-adapted patient management of non-muscle-invasive bladder cancer. Results. Non-muscle-invasive bladder cancer mainly becomes clinically apparent with painless macrohematuria. Only cystoscopy can lead to a sufficiently sound diagnosis, whereas no urinary markers providing reliable accuracy exist. Treatment usually starts with transurethral resection of the bladder tumor providing histopathological verification of the diagnosis and a basis for further treatment: in some cases it is the only treatment necessary. Histopathology guides further decision-making and provides a clear risk stratification by using some simple clinical and cystoscopical parameters. In low-risk cases transurethral resection with a single adjuvant instillation therapy early after surgery suffices, in intermediate-risk cases further outpatient instillations with a chemotherapeutic agent or bacillus Calmette-Gu,rin (BCG) follow and in high-risk cases resection is followed by repeat resection and BCG; however, cystectomy also has to be considered. In all cases a structured follow-up is mandatory. Conclusion. Despite high recurrence rates and in high-risk cases also substantial progression rates of non-muscle-invasive bladder cancer, a relatively good prognosis concerning recurrence and an advantageous prognosis concerning cancer-specific survival can be achieved using all currently available possibilities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BACILLUS-CALMETTE-GUERIN; TRANSITIONAL-CELL-CARCINOMA; RANDOMIZED CLINICAL-TRIALS; INTRAVESICAL ADJUVANT CHEMOTHERAPY; MITOMYCIN-C INSTILLATION; LONG-TERM EFFICACY; TRANSURETHRAL RESECTION; EUROPEAN-ORGANIZATION; STAGE TA; FOLLOW-UP; Macrohematuria; Cystoscopy; Transurethral resection; Instillations; Bacillus CalmetteGuerin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2020 12:51 |
| Last Modified: | 20 Mar 2020 12:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15457 |
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