Dietze-Schwonberg, Kirsten and Lorenz, Beate and Kostka, Susanna Lopez and Schumak, Beatrix and Gessner, Andre and von Stebut, Esther (2018) Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis. EXPERIMENTAL DERMATOLOGY, 27 (1). pp. 101-103. ISSN 0906-6705, 1600-0625
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Healing of leishmaniasisa parasitic skin diseaseis associated with high levels of secreted interferon (IFN) and IL-12 in resistant C57BL/6 mice and humans. Susceptible BALB/c mice predominantly react with a Th17/Th2/Treg-related immune response and finally succumb to infection. Previously, we showed that BALB/c IL-17A(-/-) mice are protected against Leishmania (L.) major infections, indicating that IL-17Apredominantly produced by Th17 cellsplays an important role for disease outcome. We now investigated DC-derived cytokines and finally identified IL-23p19 as key cytokine responsible for induction of Leishmania-specific Th17 cells that play an important role for progressive disease in susceptible BALB/c mice.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESISTANCE; IL-23; Leishmaniasis; Pathogenic; Th17 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Aug 2023 08:53 |
| Last Modified: | 01 Aug 2023 08:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15486 |
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