Hutterer, Rudi (2018) Inclusion of fluorophores in cyclodextrins: a closer look at the fluorometric determination of association constants by linear and nonlinear fitting procedures. METHODS AND APPLICATIONS IN FLUORESCENCE, 6 (1): 013001. ISSN 2050-6120,
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The author discusses methods for the fluorometric determination of affinity constants by linear and nonlinear fitting methods. This is outlined in particular for the interaction between cyclodextrins and several anesthetic drugs including benzocaine. Special emphasis is given to the limitations of certain fits, and the impact of such studies on enzyme-substrate interactions are demonstrated. Both the experimental part and methods of analysis are well suited for students in an advanced lab.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BETA-CYCLODEXTRIN; MOLECULAR RECOGNITION; PROCAINE HYDROCHLORIDE; AQUEOUS-SOLUTION; COMPLEXES; FLUORESCENCE; CHEMISTRY; ENCAPSULATION; TEMPERATURE; RECEPTORS; cyclodextrin-drug interaction; association constant; double reciprocal plot; Benesi-Hildebrand method; benzocaine; tetracaine; host-guest interaction |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2020 06:24 |
| Last Modified: | 23 Mar 2020 06:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15490 |
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