Krautbauer, Sabrina and Weiss, Thomas S. and Wiest, Reiner and Schacherer, Doris and Liebisch, Gerhard and Buechler, Christa (2017) Diagnostic Value of Systemic Cholesteryl Ester/Free Cholesterol Ratio in Hepatocellular Carcinoma. ANTICANCER RESEARCH, 37 (7). pp. 3527-3535. ISSN 0250-7005, 1791-7530
Full text not available from this repository. (Request a copy)Abstract
Background: Hepatocellular carcinoma (HCC) most commonly occurs in the setting of liver cirrhosis which is characterized by low serum lipids. We hypothesized that composition of lipoproteins and consequently lipid species ratios are mostly unchanged in patients with cirrhosis compared to controls. This approach may be appropriate to identify lipid ratios altered in HCC irrespective of liver dysfunction. Patients and Methods: Lipids were measured in serum of 21 patients with HCC, 41 patients with liver cirrhosis and 22 controls. Ratios of lipids known to be changed in HCC tissues were calculated. Results: Ratios of polyunsaturated to mono-unsaturated lysophosphatidylcholine, ceramide/sphingomyelin and cholesteryl ester/free cholesterol were changed in HCC compared to both control cohorts. The latter was most suited to diagnosing HCC. Systemic ratios of these lipid classes were not associated with fibrosis, staging or grade in patients with HCC. Conclusion: The cholesteryl ester/free cholesterol ratio is comparable in controls and patients with cirrhosis, but is specifically increased in patients with HCC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TANDEM MASS-SPECTROMETRY; HIGH-THROUGHPUT QUANTIFICATION; NONALCOHOLIC FATTY LIVER; CHRONIC HEPATITIS-B; CANCER-TREATMENT; ESI-MS/MS; CIRRHOSIS; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; STEATOHEPATITIS; Phospholipids; liver cirrhosis; cholesterol; hepatocellular carcinoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 28 Feb 2019 12:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1571 |
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