Pinto, L. A. and Michel, S. and Klopp, N. and Vogelberg, C. and von Berg, A. and Bufe, A. and Heinzmann, A. and Laub, O. and Simma, B. and Frischer, T. and Genuneit, J. and Gorski, M. and Illig, T. and Kabesch, M. (2013) Polymorphisms in the IRF-4 gene, asthma and recurrent bronchitis in children. CLINICAL AND EXPERIMENTAL ALLERGY, 43 (10). pp. 1152-1159. ISSN 0954-7894, 1365-2222
Full text not available from this repository. (Request a copy)Abstract
BackgroundInterferon-regulatory factors (IRFs) play a crucial role in immunity, not only influencing interferon expression but also T cell differentiation. IRF-4 was only recently recognized as a further major player in T cell differentiation. ObjectiveAs IRF-1 polymorphisms were shown to be associated with atopy and allergy, we comprehensively investigated effects of IRF-4 variants on allergy, asthma and related phenotypes in German children. MethodsFifteen tagging single nucleotide polymorphisms (SNPs) in the IRF-4 gene were genotyped by MALDI-TOF MS in the cross-sectional ISAAC phase II study population from Munich and Dresden (age 9-11; N=3099). Replication was performed in our previously established genome-wide association study (GWAS) data set (N=1303) consisting of asthma cases from the Multicenter Asthma Genetic in Childhood (MAGIC) study and reference children from the ISAAC II study. ResultsSNPs were not significantly associated with asthma but with bronchial hyperresponsiveness, atopy and, most interestingly, with recurrent bronchitis in the first data set. The IRF-4 variant rs9378805 was associated with recurrent bronchitis in the ISAAC population and replicated in the GWAS data set where further SNPs showed associations with recurrent bronchitis and asthma. ConclusionsWe found genetic associations in IRF-4 to be associated with recurrent bronchitis in our two study populations. Associated polymorphisms are localized in a putative regulatory element in the 3UTR region of IRF-4. These findings suggest a putative role of IRF-4 in the development of bronchitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AIRWAY INFLAMMATION; EXPRESSION; ASSOCIATION; asthma; bronchitis; children; polymorphisms; wheezing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 10:46 |
| Last Modified: | 30 Mar 2020 10:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15959 |
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