Potaczek, Daniel P. and Michel, Sven and Sharma, Vishwas and Zeilinger, Sonja and Vogelberg, Christian and von Berg, Andrea and Bufe, Albrecht and Heinzmann, Andrea and Laub, Otto and Rietschel, Ernst and Simma, Burkhard and Frischer, Thomas and Genuneit, Jon and Illig, Thomas and Kabesch, Michael (2013) Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics. PEDIATRIC ALLERGY AND IMMUNOLOGY, 24 (5). pp. 441-449. ISSN 0905-6157, 1399-3038
Full text not available from this repository. (Request a copy)Abstract
BackgroundRecently, three genome-wide association studies (GWAS) demonstrated FCER1A, the gene encoding a ligand-binding subunit of the high-affinity IgE receptor, to be a major susceptibility locus for serum IgE levels. The top association signal differed between the two studies from the general population and the one based on an asthma case-control design. In this study, we investigated whether different FCER1A polymorphisms are associated with total serum IgE in the general population and asthmatics specifically. MethodsNineteen polymorphisms were studied in FCER1A based on a detailed literature search and a tagging approach. Polymorphisms were genotyped by the Illumina HumanHap300Chip (6 polymorphisms) or MALDI-TOF MS (13 polymorphisms) in at least 1303 children (651 asthmatics) derived from the German International Study of Asthma and Allergies in Childhood II and Multicentre Asthma Genetics in Childhood Study. ResultsSimilar to two population-based GWAS, the peak association with total serum IgE was observed for SNPs rs2511211, rs2427837, and rs2251746 (mean r(2)>0.8), with the lowest p-value of 4.37x10(-6). The same 3 polymorphisms showed the strongest association in non-asthmatics (lowest p=0.0003). While these polymorphisms were also associated with total serum IgE in asthmatics (lowest p=0.003), additional polymorphisms (rs3845625, rs7522607, and rs2427829) demonstrated associations with total serum IgE in asthmatics only (lowest p=0.01). ConclusionsThese data suggest that FCER1A polymorphisms not only drive IgE levels in the general population but that specific polymorphisms may also influence IgE in association with asthma, suggesting that disease-specific mechanisms in IgE regulation exist.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FC-EPSILON-RI; HIGH-AFFINITY RECEPTOR; PROMOTER POLYMORPHISMS; ALPHA-CHAIN; ATOPIC-DERMATITIS; GENE; ASSOCIATION; PATHOGENESIS; PREVALENCE; VARIANTS; FCER1A; high-affinity IgE receptor (-subunit); immunoglobulin E; IgE; single-nucleotide polymorphism |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 10:23 |
| Last Modified: | 06 Apr 2020 10:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16319 |
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