Ellinghaus, David and Baurecht, Hansjoerg and Esparza-Gordillo, Jorge and Rodriguez, Elke and Matanovic, Anja and Marenholz, Ingo and Huebner, Norbert and Schaarschmidt, Heidi and Novak, Natalija and Michel, Sven and Maintz, Laura and Werfel, Thomas and Meyer-Hoffert, Ulf and Hotze, Melanie and Prokisch, Holger and Heim, Katharina and Herder, Christian and Hirota, Omomitsu and Tamari, Mayumi and Kubo, Michiaki and Takahashi, Atsushi and Nakamura, Yusuke and Tsoi, Lam C. and Stuart, Philip and Elder, James T. and Sun, Liangdan and Zuo, Xianbo and Yang, Sen and Zhang, Xuejun and Hoffmann, Per and Noethen, Markus M. and Foelster-Holst, Regina and Winkelmann, Juliane and Illig, Thomas and Boehm, Bernhard O. and Duerr, Richard H. and Buening, Carsten and Brand, Stephan and Glas, Juergen and McAleer, Maeve A. and Fahy, Caoimhe M. and Kabesch, Michael and Brown, Sara and McLean, W. H. Irwin and Irvine, Alan D. and Schreiber, Stefan and Lee, Young-Ae and Franke, Andre and Weidinger, Stephan (2013) High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. NATURE GENETICS, 45 (7). 808-+. ISSN 1061-4036,
Full text not available from this repository. (Request a copy)Abstract
Atopic dermatitis is a common inflammatory skin disease with a strong heritable component. Pathogenetic models consider keratinocyte differentiation defects and immune alterations as scaffolds(1), and recent data indicate a role for autoreactivity in at least a subgroup of patients(2). FLG (encoding filaggrin) has been identified as a major locus causing skin barrier deficiency(3). To better define risk variants and identify additional susceptibility loci, we densely genotyped 2,425 German individuals with atopic dermatitis (cases) and 5,449 controls using the Immunochip array followed by replication in 7,196 cases and 15,480 controls from Germany, Ireland, Japan and China. We identified four new susceptibility loci for atopic dermatitis and replicated previous associations. This brings the number of atopic dermatitis risk loci reported in individuals of European ancestry to 11. We estimate that these susceptibility loci together account for 14.4% of the heritability for atopic dermatitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; CROHNS-DISEASE; MYOCARDIAL-INFARCTION; CHROMOSOME 11Q13; COMMON VARIANT; CELIAC-DISEASE; PSORIATIC SKIN; POPULATION; ASTHMA; GENE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Apr 2020 08:31 |
| Last Modified: | 07 Apr 2020 08:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16444 |
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