Zwink, Nadine and Jenetzky, Ekkehart and Hirsch, Karin and Reifferscheid, Peter and Schmiedeke, Eberhard and Schmidt, Dominik and Reckin, Sabrina and Obermayr, Florian and Boemers, Thomas M. and Stein, Raimund and Reutter, Heiko and Roesch, Wolfgang H. and Brenner, Hermann and Ebert, Anne-Karoline (2013) Assisted Reproductive Techniques and Risk of Exstrophy-Epispadias Complex: A German Case-Control Study. JOURNAL OF UROLOGY, 189 (4). pp. 1524-1529. ISSN 0022-5347, 1527-3792
Full text not available from this repository. (Request a copy)Abstract
Purpose: We assessed the risk of exstrophy-epispadias complex in children conceived by in vitro fertilization or intracytoplasmic sperm injection. Materials and Methods: Data from the German Network for Congenital Uro-REctal malformations were compared to nationwide data from the German In Vitro Fertilization Register and the German Federal Statistical Office. Odds ratios (95% CI) were determined to quantify associations using logistic regression. Results: A total of 123 patients with exstrophy-epispadias complex born in Germany between 1997 and 2011 were recruited through participating departments of pediatric urology and pediatric surgery throughout the country as well as the German self-help organizations Blasenekstrophie/Epispadie e.V. and Kloakenekstrophie. All German live births (10,069,986) between 1997 and 2010 comprised the controls. Overall, 12 subjects (10%) and 129,982 controls (1%) were conceived by in vitro fertilization or intracytoplasmic sperm injection. Conception by assisted reproductive technique was associated with a more than eightfold increased risk of exstrophy-epispadias complex compared to spontaneous conception (OR 8.3, 95% CI 4.6-15.0, p < 0.001). Separate analyses showed a significantly increased risk of exstrophy-epispadias complex in children conceived by in vitro fertilization (OR 14.0, 95% CI 6.5-30.0, p < 0.0001) or intracytoplasmic sperm injection (OR 5.3, 95% CI 2.2-12.9, p < 0.0001). Conclusions: This study provides evidence that assisted reproductive techniques such as in vitro fertilization and intracytoplasmic sperm injection are associated with a markedly increased risk of having a child born with exstrophy-epispadias complex. However, it remains unclear whether this finding may be due to assisted reproduction per se and/or underlying infertility/subfertility etiology or parent characteristics.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BIRTH-DEFECTS; FAMILIES; TECHNOLOGIES; BORN; bladder exstrophy and epispadias complex; congenital abnormalities; pregnancy; reproductive medicine; reproductive techniques, assisted |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Apr 2020 09:10 |
| Last Modified: | 17 Apr 2020 09:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16890 |
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