Nyuyki, Kewir D. and Beiderbeck, Daniela I. and Lukas, Michael and Neumann, Inga D. and Reber, Stefan O. (2012) Chronic Subordinate Colony Housing (CSC) as a Model of Chronic Psychosocial Stress in Male Rats. PLOS ONE, 7 (12): e52371. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Chronic subordinate colony housing (CSC) is an adequate and reliable mouse model of chronic psychosocial stress, resulting in reduced body weight gain, reduced thymus and increased adrenal weight, long-lasting anxiety-like behaviour, and spontaneous colitis. Furthermore, CSC mice show increased corticotrophin (ACTH) responsiveness to acute heterotypic stressors, suggesting a general mechanism which allows a chronically-stressed organism to adequately respond to a novel threat. Therefore, the aim of the present study was to extend the CSC model to another rodent species, namely male Wistar rats, and to characterize relevant physiological, immunological, and behavioural consequences; placing particular emphasis on changes in hypothalamo-pituitary-adrenal (HPA) axis responsiveness to an acute heterotypic stressor. In line with previous mouse data, exposure of Wistar rats to 19 days of CSC resulted in a decrease in body weight gain and absolute thymus mass, mild colonic barrier defects and intestinal immune activation. Moreover, no changes in stress-coping behaviour or social preference were seen; again in agreement with the mouse paradigm. Most importantly, CSC rats showed an increased plasma corticosterone response to an acute heterotypic stressor (open arm, 5 min) despite displaying similar basal levels and similar basal and stressor-induced plasma ACTH levels. In contrast to CSC mice, anxiety-related behaviour and absolute, as well as relative adrenal weights remained unchanged in CSC rats. In summary, the CSC paradigm could be established as an adequate model of chronic psychosocial stress in male rats. Our data further support the initial hypothesis that adrenal hyper-responsiveness to ACTH during acute heterotypic stressors represents a general adaptation, which enables a chronically-stressed organism to adequately respond to novel challenges.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PITUITARY-ADRENAL AXIS; CHRONIC SOCIAL STRESS; CORTICOTROPIN-RELEASING-FACTOR; DSS-INDUCED COLITIS; NUCLEUS-ACCUMBENS; FEMALE RATS; HYPOTHALAMIC VASOPRESSIN; LABORATORY RATS; GUT DYSFUNCTION; DEFEAT STRESS; |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Apr 2020 06:36 |
| Last Modified: | 30 Apr 2020 06:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17577 |
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