Zigmond, Ehud and Varol, Chen and Farache, Julia and Elmaliah, Elinor and Satpathy, Ansuman T. and Friedlander, Gilgi and Mack, Matthias and Shpigel, Nahum and Boneca, Ivo G. and Murphy, Kenneth M. and Shakhar, Guy and Halpern, Zamir and Jung, Steffen (2012) Ly6C(hi) Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells. IMMUNITY, 37 (6). pp. 1076-1090. ISSN 1074-7613,
Full text not available from this repository. (Request a copy)Abstract
Ly6C(hi) monocytes seed the healthy intestinal lamina propria to give rise to resident CX(3)CR1(+) macrophages that contribute to the maintenance of gut homeostasis. Here we report on two alternative monocyte fates in the inflamed colon. We showed that CCR2 expression is essential to the recruitment of Ly6C(hi) monocytes to the inflamed gut to become the dominant mononuclear cell type in the lamina propria during settings of acute colitis. In the inflammatory microenvironment, monocytes upregulated TLR2 and NOD2, rendering them responsive to bacterial products to become proinflammatory effector cells. Ablation of Ly6C(hi) monocytes ameliorated acute gut inflammation. With time, monocytes differentiated into migratory antigen-presenting cells capable of priming naive T cells, thus acquiring hallmarks reminiscent of dendritic cells. Collectively, our results highlight cellular dynamics in the inflamed colon and the plasticity of Ly6C(hi) monocytes, marking them as potential targets for inflammatory bowel disease (IBD) therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD103(+) DENDRITIC CELLS; REGULATORY T-CELLS; INTESTINAL HOMEOSTASIS; EXPERIMENTAL COLITIS; BACTERIAL-INFECTION; LAMINA-PROPRIA; MACROPHAGES; INFLAMMATION; MICE; RECOGNITION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Apr 2020 10:12 |
| Last Modified: | 30 Apr 2020 10:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17599 |
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