Jung, G. and Troidl, K. and Apfelbeck, H. and Troidl, C. and Wietelmann, A. and Mueller, C. and Winterbauer, C. and Schaper, W. and Schmitz-Rixen, T. (2012) Induction of peripheral arteriogenesis. Description and comparison of animal experimental standards of ligation of the femoral artery and ligation in combination with a distal artiovenous fistula. GEFASSCHIRURGIE, 17 (8). pp. 721-726. ISSN 0948-7034, 1434-3932
Full text not available from this repository. (Request a copy)Abstract
Arteriogenesis, the growth of preformed collateral arteries into functional conductance vessels, is a natural mechanism, which can be induced in animal models. Elevating the fluid shear stress on vessel endothelium is crucial for arteriogenesis and is generally induced by arterial occlusion. Two models to induce peripheral arteriogenesis are described. Ligating the femoral artery of the mouse hindlimb is a standardised model which leads to collateral growth in the thigh muscles. To enhance the effect of a simple ligature, the shunt-model, which combines the ligature with an arteriovenous fistula of a femoral artery and vein distal to the occlusion, may be employed. As a consequence the blood flow is drained directly into the venous system, causing chronically elevated shear stress and a maximal stimulus for arteriogenesis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FLUID SHEAR-STRESS; VASCULAR ENDOTHELIAL-CELLS; HINDLIMB ISCHEMIA; GENE-EXPRESSION; PROTEIN-KINASES; VESSEL GROWTH; ANGIOGENESIS; CIRCULATION; INVOLVEMENT; MODEL; Arteriogenesis; Shear stress; Collateral arteries; Ligation; Arteriovenous fistula |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 May 2020 05:12 |
| Last Modified: | 04 May 2020 05:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17638 |
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