Lodde, M. and Mayr, R. and Martini, T. and Comploj, E. and Palermo, S. and Trenti, E. and Hanspeter, E. and Fritsche, H. M. and Mian, C. and Pycha, A. (2012) Positive urine cytology and carcinoma in situ prior to second transurethral resection of the bladder correlate with positive second resection histology and the need for subsequent cystectomy. WORLD JOURNAL OF UROLOGY, 30 (6). pp. 841-846. ISSN 0724-4983,
Full text not available from this repository. (Request a copy)Abstract
A second transurethral resection of the bladder (TURB) is recommended for high-grade bladder cancer (BC) yet yields negative results in over half of the cases. Aim of this study was to identify prognostic indicators of a positive second TURB or the need for a subsequent cystectomy. The study cohort consisted of 101 patients with high-risk BC (T1G2-3, TaG3, Carcinoma in situ) who underwent second TURB after complete first resection. Age, gender, stage, grade, carcinoma in situ (Cis), tumour number, size, localization, surgeon experience and bladder wash cytology before the second TURB were considered as potential prognostic factors of positive histology at second TURB or the need for subsequent cystectomy. The mean follow-up period was 23.8 months. The study cohort was comprised of 82 males and 17 females. Cytology on bladder wash urine was performed in 85/101 patients and in 39 was negative; 55.5 % of second TURB specimens were negative. The rate of upstaging to a parts per thousand yenT2 was 4.9 %. Cis (OR 8.4; 95 % CI 1.3-54.2; p = 0.03) and positive cytology (OR 6.8; 95 % CI 2.3-19.9; p = < 0.01) were independent prognostic factors of a residual tumour in the second TURB. Cytology also correlated with clinical need for cystectomy in the follow-up (HR 6.5; 95 % CI 1.3-30.5; p = 0.02). CIS and positive cytology prior to second TURB increased the risk of a positive second TURB specimen. A positive cytology also increases the risk of the subsequent need for cystectomy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; UROTHELIAL CARCINOMA; CANCER; RECURRENCE; VARIABILITY; QUALITY; UPDATE; TUMORS; MUSCLE; RISK; Urothelial carcinoma; Cytology; Bladder cancer; Transurethral resection; Cystectomy; Staging; Second transurethral resection; High-grade |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 May 2020 05:51 |
| Last Modified: | 04 May 2020 05:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17691 |
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