Alichniewicz, Karolina K. and Brunner, Florian and Kluenemann, Hans H. and Greenlee, Mark W. (2012) Structural and functional neural correlates of visuospatial information processing in normal aging and amnestic mild cognitive impairment. NEUROBIOLOGY OF AGING, 33 (12). pp. 2782-2797. ISSN 0197-4580, 1558-1497
Full text not available from this repository. (Request a copy)Abstract
Our understanding of cognitive changes related to human aging and their underlying neural processes is challenged by the distinction between normal and pathological aging. In our study, the neural correlates of visuospatial working memory (VSWM) in young persons (YC), healthy older adults (HC) and patients with amnestic mild cognitive impairment (aMCI) were investigated. Effects of the genetic risk factor apolipoprotein E (ApoE) epsilon 4 on a VSWM task were analyzed for HC and aMCI patients. Higher cortical activation in extrastriate occipital regions and significantly decreased brain volumes in frontoparietal areas were observed in HC compared with young persons. Also, reduced cortical activation in the right middle frontal gyrus and superior frontal gyrus was observed in aMCI-patients compared with HC. Thus, attenuated cortical activation during VSWM tasks is related to the formation of aMCI and may serve as an early marker for cognitive decline. In contrast to previous studies, no significant apolipoprotein E-linked differences were found between HC and aMCI groups. (C) 2012 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EARLY ALZHEIMERS-DISEASE; WORKING-MEMORY PARADIGM; VOXEL-BASED MORPHOMETRY; GRAY-MATTER VOLUME; APOLIPOPROTEIN-E; SYSTEMATIC METAANALYSES; ASSOCIATION WORKGROUPS; INDIVIDUAL-DIFFERENCES; DIAGNOSTIC GUIDELINES; CORTICAL ACTIVATION; Mild cognitive impairment; Alzheimer's disease; Functional magnetic resonance imaging; Working memory; Apolipoprotein E; Aging |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Human Sciences > Institut für Psychologie Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 May 2020 06:32 |
| Last Modified: | 04 May 2020 06:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17727 |
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