Bauer, Sabrina and Eisinger, Kristina and Wiest, Reiner and Karrasch, Thomas and Scherer, Marcus N. and Farkas, Stefan and Aslanidis, Charalampos and Buechler, Christa (2012) Connective tissue growth factor level is increased in patients with liver cirrhosis but is not associated with complications or extent of liver injury. REGULATORY PEPTIDES, 179 (1-3). pp. 10-14. ISSN 0167-0115, 1873-1686
Full text not available from this repository. (Request a copy)Abstract
Connective tissue growth factor (CTGF) is a profibrotic protein whose systemic levels are increased in liver cirrhosis. Here, association of CTGF with stages of liver injury and complications of cirrhotic liver disease has been analyzed in patients with different aetiologies of hepatic injury. CTGF is significantly increased in portal venous serum (PVS), hepatic venous serum (HVS) and systemic venous serum (SVS) of 46 patients with liver cirrhosis compared to eight liver-healthy controls. In patients blood samples CTGF in HVS is about 6% higher than PVS levels indicating that CTGF produced in the liver is released to the circulation. CTGF is not associated with stages of liver cirrhosis defined by CHILD-PUGH or MELD score nor with secondary complications of portal hypertension (varices, ascites, spontaneous bacterial peritonitis). Transforming growth factor beta (TGF beta) induces CTGF synthesis in hepatocytes and a positive association of systemic TGF beta 1 and SVS and HVS CTGF is found. Three months after placing transjugular intrahepatic portosystemic shunt (TIPS) hepatic venous pressure gradient is reduced whereas CHILD-PUGH score, TGF beta 1 and CTGF are not altered in serum of 15 patients. Current data show that the cirrhotic liver releases little CTGF but SVS, HVS and PVS CTGF levels are not associated with residual liver function and complications of cirrhosis. (C) 2012 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATIC STELLATE CELLS; FACTOR CTGF/CCN2; HEPATORENAL-SYNDROME; FIBROSIS; ASCITES; HEPATOCYTES; EXPRESSION; GALECTIN-3; OBESITY; SERUM; Hepatic vein; TIPS; CHILD-PUGH stage; CTGF |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 May 2020 08:12 |
| Last Modified: | 04 May 2020 08:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17809 |
Actions (login required)
 |
View Item |
