Nothdurfter, Caroline and Baghai, Thomas C. and Schuele, Cornelius and Rupprecht, Rainer (2012) Translocator protein (18 kDa) (TSPO) as a therapeutic target for anxiety and neurologic disorders. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 262. S107-S112. ISSN 0940-1334, 1433-8491
Full text not available from this repository. (Request a copy)Abstract
The translocator protein (18kD) (TSPO) plays a crucial role for the synthesis of neurosteroids by promoting the transport of cholesterol to the inner mitochondrial membrane, which is the rate-limiting step in neurosteroidogenesis. Neurosteroids are allosteric modulators of GABA(A) receptor function, which plays an important role in the pathophysiology of anxiety disorders. The TSPO ligand XBD173 enhances GABAergic neurotransmission by promoting neurosteroidogenesis without direct effects at the GABAA receptor. In humans, XBD173 shows potent antipanic efficacy without sedation and withdrawal after 7 days of treatment. XBD173 therefore appears to be a promising compound for rapid anxiolytic efficacy with a favorable side-effect profile. Furthermore, TSPO ligands show neuroprotective and antiinflammatory effects in experimental models of peripheral neuropathies and traumatic brain injury. These compounds might therefore also be valuable for the treatment of neurologic diseases with inflammation-related pathophysiology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERIPHERAL BENZODIAZEPINE-RECEPTOR; NEUROACTIVE STEROIDS; ANXIOLYTIC ETIFOXINE; CHOLESTEROL-BINDING; NERVOUS-SYSTEM; PANIC DISORDER; MESSENGER-RNA; EXPRESSION; STRESS; STEROIDOGENESIS; TSPO; Neurosteroid; Anxiety disorder; GABA(A) receptor; Neuroregeneration |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 May 2020 08:00 |
| Last Modified: | 26 May 2020 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17823 |
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