Thiel, U. and Wolf, P. and Wawer, A. and Blaeschke, F. and Grunewald, T. G. P. and von Luettichau, I. T. and Klingebiel, T. and Bader, P. and Borkhardt, A. and Laws, H. -J. and Handgretinger, R. and Lang, P. and Schlegel, P. G. and Eyrich, M. and Gruhn, B. and Ehninger, G. and Koscielniak, E. and Klein, C. and Sykora, K. -W. and Holler, E. and Mauz-Koerholz, C. and Woessmann, W. and Richter, G. H. S. and Schmidt, A. H. and Peters, C. and Dirksen, U. and Juergens, H. and Bregni, M. and Burdach, S. (2012) Human Leukocyte Antigen Distribution in German Caucasians with Advanced Ewing's Sarcoma. KLINISCHE PADIATRIE, 224 (6). pp. 353-358. ISSN 0300-8630,
Full text not available from this repository. (Request a copy)Abstract
Background: Risk stratification criteria for patients with Ewing's sarcoma family of tumors (ESFT) are still limited. We hypothesized divergent human leukocyte antigen (HLA) patterns in ESFT patients and compared HLA-A, -B and -DR phenotype frequencies of patients with advanced ESFT with those of healthy controls. Patients: HLA types of all German Caucasian patients with advanced ESFT and available HLA-A, -B and -DR data registered in the European Group for Blood and Marrow Transplantation, Paediatric Registry for Stem Cell Transplantation and the MetaEICESS data bases (study group, n=30) were retrospectively compared with HLA types of healthy German stem cell donors (control group, n=8862 for single HLA frequencies and n=8839 for allele combinations). Study group patients had been immuno-typed due to eligibility for allogeneic stem cell transplantation for high risk of treatment failure, and thus constituted a selected subgroup of ESFT patients. Results: After Bonferroni correction for multiple testing (PC), phenotype frequencies of HLA-A24 remained significantly higher in the study group compared to controls (PC < 0.05). Furthermore, several HLA combinations were significantly more frequent in the study group compared to controls (all PC < 0.05). Conclusion: We report an increased incidence of circumscribed HLA patterns in German Caucasians with advanced ESFT. The possible clinical significance of this observation has to be re-assessed in prospective trials comprising larger ESFT patient numbers of all risk groups.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; T-CELLS; EUROPEAN INTERGROUP; TUMOR PATIENTS; ASSOCIATION; IMMUNOTHERAPY; EXPRESSION; BONE; RECOGNITION; CHILDREN; Ewing's sarcoma; human leukocyte antigens; risk stratification; biomarkers; immunosurveillance; allogeneic stem cell transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 May 2020 04:37 |
| Last Modified: | 05 May 2020 04:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17834 |
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