Nedialkov, Paraskev T. and Kokanova-Nedialkova, Zlatina and Buecherl, Daniel and Momekov, Georgi and Heilmann, Joerg and Nikolov, Stefan (2012) 30-Normedicagenic Acid Glycosides from Chenopodium foliosum. NATURAL PRODUCT COMMUNICATIONS, 7 (11). pp. 1419-1422. ISSN 1934-578X,
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Two new glycosides of 30-normedicagenic acid, namely 3-O-[beta-D-glucuronopyranosyl methyl ester]-2 beta,3 beta-dihydroxy-30-noroleane-12,20(29)-diene-23,28-dioic acid 28-O-beta-D-glucopyranosyl ester, and 3-O-beta-D-glucopyranosyl-2 beta,3 beta-dihydroxy-30-noroleane-12,20(29)-diene-23,28-dioic acid, together with the known 3-O-beta-glucopyranosyl-2 beta,3 beta-dihydroxy-30-noroleane-12,20(29)-diene-23,28-dioic acid 28-O-beta-glucopyranosyl ester, and 3-O-beta-glucuronopyranosyl-2 beta,3 beta-dihydroxy-30-noroleane-12,20(29)-diene-23,28-dioic acid 28-O-beta-glucopyranosyl ester were isolated from the aerial parts of Chenopodium foliosum Asch. The structures of the compounds were determined by means of spectroscopic methods (ID and 2D NMR, UV, IR) and HRMS-ESI. The compounds were tested for cytotoxicity on three leukemic cell lines (BV-173, SKW-3, HL-60). In addition, the saponins showed moderate stimulatory effects on interleukin-2 production in PHA/PMA stimulated Jurkat E6.1 cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRITERPENOID SAPONINS; INFLAMMATORY CYTOKINES; INTERLEUKIN-2; CONSTITUENTS; ACTIVATION; MOLECULES; CELLS; SEEDS; Chenopodium foliosum; 30-Normedicagenic acid; Triterpene saponin; Cytotoxicity; Interleukin-2 |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 May 2020 04:53 |
| Last Modified: | 05 May 2020 04:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17850 |
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