Kabesch, Michael and Adcock, Ian M. (2012) Epigenetics in asthma and COPD. BIOCHIMIE, 94 (11). pp. 2231-2241. ISSN 0300-9084, 1638-6183
Full text not available from this repository. (Request a copy)Abstract
Epigenetic mechanisms are likely to play a role in many complex diseases, the extent of which we only beginning to understand. COPD and asthma are two respiratory diseases subject to strong environmental influences depending on underlying genetic susceptibility. Epigenetic mechanisms such as DNA methylation, histone modification and microRNA may be involved in these processes by modulating environmental effects to influence disease development. Given their demonstrated modifiable nature, epigenetic mechanisms may open new possibilities for therapeutic intervention. Here we give an overview of recent developments in the field of respiratory epigenetics in relation to asthma and COPD in the context of our current understanding of mechanisms leading to such diseases. (C) 2012 Published by Elsevier Masson SAS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OBSTRUCTIVE PULMONARY-DISEASE; ALLERGIC AIRWAYS DISEASE; NF-KAPPA-B; HISTONE DEACETYLASE ACTIVITY; CD8(+) T-CELLS; DNA METHYLATION; GENE-EXPRESSION; CHILDHOOD ASTHMA; CYTOKINE GENES; CHROMATIN MODIFICATION; Asthma; COPD; Epigenetic; Methylation; Histone acetylation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 May 2020 06:01 |
| Last Modified: | 26 May 2020 06:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17862 |
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