Roll, Petra and Ostermeier, Eva and Haubitz, Marion and Lovric, Svjetlana and Unger, Leonore and Holle, Julia and Koetter, Ina and Henes, Joerg C. and Bergner, Raoul and Rubbert-Roth, Andrea and Specker, Christof and Schulze-Koops, Hendrik and Mueller-Ladner, Ulf and Fleck, Martin and Burmester, Gerd-Ruediger and Hiepe, Falk and Heitmann, Stefan and Aringer, Martin and Fischer-Betz, Rebecca and Doerner, Thomas and Tony, Hans-Peter (2012) Efficacy and Safety of Rituximab Treatment in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitides: Results from a German Registry (GRAID). JOURNAL OF RHEUMATOLOGY, 39 (11). pp. 2153-2156. ISSN 0315-162X,
Full text not available from this repository. (Request a copy)Abstract
Objective. Rituximab (RTX) therapy is a treatment option in patients with refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We investigated the tolerability and clinical efficacy of RTX in a cohort of patients with refractory AAV. Methods. Clinical and safety data of patients with AAV treated with RTX were retrospectively assessed from the data of a German national registry. Results. In total, 58 patients were included in this analysis (50/58 with granulomatosis with polyangiitis; 8/58 with microscopic polyangiitis who received at least I cycle, 17 patients who received 2 cycles, and 3 patients who received 3 cycles of RTX). Response was classified as complete and partial in 22 (40%) and in 29 cases (52.7%), respectively. Four patients (7.3%) were classified as nonresponders. Conclusion. RTX was well tolerated with good clinical efficacy in patients with refractory AAV. (First Release Sept 15 2012; J Rheumatol 2012;39:2153-6; doi:10.3899/jrheum.120482)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WEGENERS-GRANULOMATOSIS; THERAPY; CYCLOPHOSPHAMIDE; MANIFESTATIONS; EXPERIENCE; DEPLETION; RITUXIMAB; EFFICACY; SAFETY; ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIDES |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 May 2020 05:01 |
| Last Modified: | 05 May 2020 05:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17864 |
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