Neumann, Inga D. and Landgraf, Rainer (2012) Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. TRENDS IN NEUROSCIENCES, 35 (11). pp. 649-659. ISSN 0166-2236, 1878-108X
Full text not available from this repository. (Request a copy)Abstract
Oxytocin and vasopressin are regulators of anxiety, stress-coping, and sociality. They are released within hypothalamic and limbic areas from dendrites, axons, and perikarya independently of, or coordinated with, secretion from neurohypophysial terminals. Central oxytocin exerts anxiolytic and antidepressive effects, whereas vasopressin tends to show anxiogenic and depressive actions. Evidence from pharmacological and genetic association studies confirms their involvement in individual variation of emotional traits extending to psychopathology. Based on their opposing effects on emotional behaviors, we propose that a balanced activity of both brain neuropeptide systems is important for appropriate emotional behaviors. Shifting the balance between the neuropeptide systems towards oxytocin, by positive social stimuli and/or psychopharmacotherapy, may help to improve emotional behaviors and reinstate mental health.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECEPTOR GENE OXTR; CORTICOTROPIN-RELEASING-FACTOR; MESSENGER-RNA EXPRESSION; PITUITARY-ADRENAL AXIS; STRESS RESPONSES; PARAVENTRICULAR NUCLEUS; ARGININE-VASOPRESSIN; CENTRAL AMYGDALA; MALE RATS; HYPOTHALAMIC VASOPRESSIN; anxiety; depression; neuropeptide balance; oxytocin; social behavior; vasopressin |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 May 2020 07:58 |
| Last Modified: | 26 May 2020 07:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17868 |
Actions (login required)
 |
View Item |
