Kunzelmann, Karl and Tian, Yuemin and Martins, Joana Raquel and Faria, Diana and Kongsuphol, Patthara and Ousingsawat, Jiraporn and Wolf, Luisa and Schreiber, Rainer (2012) Airway epithelial cells-Functional links between CFTR and anoctamin dependent Cl- secretion. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 44 (11). pp. 1897-1900. ISSN 1357-2725, 1878-5875
Full text not available from this repository. (Request a copy)Abstract
Airways consist of a heterogeneous population of cells, comprising ciliated cells, Clara cells and goblet cells. Electrolyte secretion by the airways is necessary to produce the airway surface liquid that allows for mucociliary clearance of the lungs. Secretion is driven by opening of Cl- selective ion channels in the apical membrane of airway epithelial cells, through either receptor mediated increase in intracellular cAMP or cytosolic Ca2+. Traditionally cAMP-dependent and Ca2+-dependent secretory pathways are regarded as independent. However, this concept has been challenged recently. With identification of the Ca2+ activated Cl- channel TMEM16A (anoctamin 1) and with detailed knowledge of the cAMP-regulated cystic fibrosis transmembrane conductance regulator (CFTR), it has become possible to look more closely into this relationship. (c) 2012 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CYSTIC-FIBROSIS; CA2+; TMEM16A; CAMP; Ca2+ activated Cl- currents; CaCC; TMEM16A; Ano1; Anoctamin; CFFR; Crosstalk |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 May 2020 12:37 |
| Last Modified: | 04 May 2020 12:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17899 |
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