Wang, Xu-dong and Meier, Robert J. and Wolfbeis, Otto S. (2012) A Fluorophore-Doped Polymer Nanomaterial for Referenced Imaging of pH and Temperature with Sub-Micrometer Resolution. ADVANCED FUNCTIONAL MATERIALS, 22 (20). pp. 4202-4207. ISSN 1616-301X,
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A new kind of pH and temperature sensitive material is reported. It is composed of dye-doped polymer nanoparticles incorporated into a thin film of a polyurethane hydrogel. The new pH/temperature-sensitive nanoparticles are obtained by post-staining oxygen-impermeable amino-functionalized polyacrylonitrile nanoparticles with a long-lifetime reference dye. Staining is followed by covalently linking fluorescein isothiocyanate onto the surface of the nanoparticle. The new sensor material has several distinct features: a) it enables imaging of pH via time domain dual-lifetime referencing; b) effects of temperature on pH sensing may be compensated for; and c) temperature can simultaneously be visualized via rapid lifetime imaging. The new material enables referenced and temperature-compensated pH imaging with superior spatial resolution due to the use of nanosized sensor nanoparticles.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERMEATION-SELECTIVE MICROBEADS; OPTICAL SENSOR; IN-VIVO; MICROFLUIDIC SYSTEMS; DISSOLVED-OXYGEN; TIME-DOMAIN; LIFETIME; FLUORESCENT; COMPLEXES; GRADIENT; organic polymer nanoparticles; pH imaging; temperature imaging; sensor materials; fluorescence |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 May 2020 05:19 |
| Last Modified: | 05 May 2020 05:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17929 |
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