Schiffner, Susanne and Chen, Suzie and Becker, Juergen C. and Bosserhoff, Anja-Katrin (2012) Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases. EXPERIMENTAL DERMATOLOGY, 21 (10). pp. 786-788. ISSN 0906-6705,
Full text not available from this repository. (Request a copy)Abstract
Murine model systems are critically required tools for the investigation of unknown mechanisms of melanoma development and metastasis and for developing more efficient therapies. The Tg(Grm1)EPv melanoma mouse model is characterized by spontaneous development of pigmented cutaneous melanomas at hairless skin regions, with a short latency and 100% penetrance. Local metastasis was described in initial analyses; however, melanoma cells were not observed in distant organs. Here, we demonstrate that the established Tg(Grm1)EPv melanoma mouse model exhibits more extensive metastasis into distant organs than previously described. Disseminated cells undergo phenotypic changes, as we observed high numbers of non-pigmented Grm1-expressing melanoma cells within distant organs. As such changes during metastasis are common in human melanoma, our findings demonstrate that this mouse model represents an even more useful tool to study unknown mechanisms of metastasis in human melanoma than previously assumed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METABOTROPIC GLUTAMATE-RECEPTOR-1; TRANSGENIC MICE; GRM1; GRM1; melanoma; metastasis; mouse model |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 May 2020 05:49 |
| Last Modified: | 05 May 2020 05:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18013 |
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