Schmidt, Sebastian and Juergenliemk, Guido and Schmidt, Thomas J. and Skaltsa, Helen and Heilmann, Joerg (2012) Bi-, Tri-, and Polycyclic Acylphloroglucinols from Hypericum empetrifolium. JOURNAL OF NATURAL PRODUCTS, 75 (10). pp. 1697-1705. ISSN 0163-3864, 1520-6025
Full text not available from this repository. (Request a copy)Abstract
The H-1 NMR-guided fractionation of a petroleum ether extract of Hypericum empetrifolium led to the isolation of four new bicyclic (1-4), four known bicyclic (5-8), three new tricyclic (9-11), and three new polycyclic acylphloroglucinols (12/13 and 14) possessing a monoterpenoid citran moiety. Compounds 12/13 were isolated as a mixture of two inseparable structural isomers. The compounds showed in vitro antiproliferative activity against human microvascular endothelial cells (HMEC-1) with IC50 values in the range 9.2 +/- 2.0 to 29.6 +/- 3.5 mu M.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHLOROGLUCINOL DERIVATIVES; ANGIOGENESIS; PAPUANUM; CELLS; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 May 2020 08:46 |
| Last Modified: | 05 May 2020 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18015 |
Actions (login required)
 |
View Item |
