Arzt, Michael and Luigart, Ruth and Schum, Carola and Luethje, Lars and Stein, Annika and Koper, Iris and Hecker, Cornelia and Dumitrascu, Rio and Schulz, Richard (2012) Sleep-disordered breathing in deep vein thrombosis and acute pulmonary embolism. EUROPEAN RESPIRATORY JOURNAL, 40 (4). pp. 919-924. ISSN 0903-1936, 1399-3003
Full text not available from this repository. (Request a copy)Abstract
Sleep-disordered breathing (SOB) may trigger thromboembolic events by enhancing intravascular clot formation. The primary objective of the present nested case-control study was to investigate whether the prevalence of SDB is increased in patients with deep vein thrombosis (DVT) and/or acute pulmonary embolism (PE). 82 consecutive patients with DVT and/or PE (cases) were prospectively enrolled irrespective of SDB-related symptoms and formed matched pairs with patients without DVT and/or PE (controls) according to sex and pre-defined categories of age and body mass index. The prevalence of SDB (respiratory disturbance index assessed by polygraphy >= 15 events.h(-1)) was significantly greater in the cases with DVT and/or PE than in controls (40 versus 26%, p=0.046) and was predominantly obstructive in nature. Multiple regression analysis revealed that SDB was significantly associated with DVT and/or PE (OR 2.28, 95% CI 1.08-4.85; p=0.032) independent of established risk factors for thrombosis. In the sex-specific analyses this association was significant in females (OR 4.14, 95% CI 1.05-16.36; p=0.042), but not in males (OR 1.55, 95% CI 0.57-4.21; p=0.391). SDB occurs more frequently in females with DVT and/or PE than in controls matched for anthropometric variables, and is independently associated with the occurrence of these thromboembolic events.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSITIVE AIRWAY PRESSURE; ENDOTHELIAL FUNCTION; APNEA SYNDROME; AGGREGATION; PREVALENCE; SEVERITY; Pulmonary embolism; sleep apnoea; thrombosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Zentren des Universitätsklinikums Regensburg > Universitäres Schlafmedizinisches Zentrum Regensburg - Donaustauf |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 May 2020 08:48 |
| Last Modified: | 05 May 2020 08:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18017 |
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