Beier, Christoph P. and Kumar, Praveen and Meyer, Katharina and Leukel, Petra and Bruttel, Valentin and Aschenbrenner, Ines and Riemenschneider, Markus J. and Fragoulis, Athanassios and Ruemmele, Petra and Lamszus, Katrin and Schulz, Joerg B. and Weis, Joachim and Bogdahn, Ulrich and Wischhusen, Joerg and Hau, Peter and Spang, Rainer and Beier, Dagmar (2012) The Cancer Stem Cell Subtype Determines Immune Infiltration of Glioblastoma. STEM CELLS AND DEVELOPMENT, 21 (15). pp. 2753-2761. ISSN 1547-3287,
Full text not available from this repository. (Request a copy)Abstract
Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. In contrast, proneural GBM CSCs resisted TGF-beta due to TGFR2 deficiency. In vivo, a substantially increased infiltration of immune cells was observed in mesenchymal GBMs, while immune infiltrates were rare in proneural GBMs. On a functional level, proneural CSC lines caused a significantly stronger TGF-beta-dependent suppression of NKG2D expression on CD8(+) T and NK cells in vitro providing a mechanistic explanation for the reduced immune infiltration of proneural GBMs. Thus, the molecular subtype of CSCs TGF-beta-dependently contributes to the degree of immune infiltration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TGF-BETA; SELF-RENEWAL; GLIOMA-CELLS; IN-VIVO; GROWTH; EXPRESSION; PROFILES; LINES; INVASIVENESS; SUBCLASSES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Abteilung für Neuropathologie Medicine > Lehrstuhl für Pathologie Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 May 2020 09:22 |
| Last Modified: | 05 May 2020 09:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18025 |
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